Bazan, Sk Sarif Hassan, Pritam Kumar Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla, Wagner Baetas-da-Cruz, Yogendra Kumar Mishra, Giorgio Palu, Adam M. You should not think of this need for opt-ins as a roadblock or delay to. Sherchan, Gajendra Kumar Azad, Nima Rezaei, Ángel Serrano-Aroca, Nicolas G. Learn the most important text message privacy laws that your business needs to. The only justification for stopping citizens under a roadblock scenario is to warn them of unseen peril that could cause injury or death. Redwan, Parise Adadi, Gaurav Chauhan, Samendra P. What is a Roadblock A roadblock is a barricade set up by law enforcement to selectively stop and question motorists. Aljabali, Tarek Mohamed Abd El-Aziz, Amos Lal, Elrashdy M. Lundstrom, Kenneth, Debmalya Barh, Bruce D. COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street? Biomolecules. Lundstrom K, Barh D, Uhal BD, Takayama K, Aljabali AAA, Abd El-Aziz TM, Lal A, Redwan EM, Adadi P, Chauhan G, Sherchan SP, Azad GK, Rezaei N, Serrano-Aroca Á, Bazan NG, Hassan SS, Panda PK, Pal Choudhury P, Pizzol D, Kandimalla R, Baetas-da-Cruz W, Mishra YK, Palu G, Brufsky AM, Tambuwala MM, Uversky VN. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia and if necessary, a reformulation of existing vaccines. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Similar findings have been reported for several viral diseases after vaccine administration. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19).